Epithal-X Capsules

What Is BioMind?

BioMind is a three-in-one neurocognitive research compound designed to explore neuroplasticity, cognitive function, and neuroprotection in a research environment. It combines J-147, Dihexa, and Noopept, which individually and synergistically support brain health and resilience against neurodegeneration.

• J-147 (10mg per serving *): A neuroprotective compound that modulates mitochondrial function and increases BDNF, which leads to the reduction of neuroinflammation and oxidative stress while possibly improving cognitive function.
• Dihexa (10mg per serving *): A synaptic growth promoter that enhances neural connectivity and repair, mimicking natural neurotrophic factors like HGF.
• Noopept (10mg per serving *): A dipeptide nootropic that modulates neurotransmission and protects neurons from excitotoxicity.

* serving size = 2 capsules

Together, these compounds offer a unique research opportunity to study cognitive resilience, neurodegenerative disease mechanisms, and neural regeneration in preclinical models.

BioMind Research Compounds and Mechanisms

1. J-147 – Mitochondrial Modulation and Neuroprotection

J-147 is a novel neuroprotective agent that enhances mitochondrial function, promotes cellular longevity pathways, and protects against oxidative stress.

• Increases levels of brain-derived neurotrophic factor (BDNF), promoting neuroplasticity.
• Modulates AMPK/mTOR pathways, which are linked to cellular energy regulation and anti-aging effects.
• Protects neurons from oxidative stress and excitotoxicity, reducing markers of neuroinflammation and neuronal death.
• Improves memory and learning ability in preclinical models of Alzheimer’s disease and cognitive decline.
• Crosses the blood-brain barrier efficiently, enabling direct action on brain mitochondria and synapses.

Research has demonstrated J-147’s ability to reverse cognitive deficits, reduce amyloid plaque burden, and enhance synaptic density, making it a valuable tool for studying neurodegeneration, cognitive enhancement, and longevity pathways.

1. Dihexa – Synaptogenesis and Neural Repair

Dihexa is a synthetic neurotrophic compound derived from angiotensin IV, designed to stimulate synapse formation and neural repair.

• Binds and activates hepatocyte growth factor (HGF) receptors, promoting synaptogenesis and neural connectivity.
• Enhances long-term potentiation (LTP), a fundamental mechanism for memory consolidation and learning.
• Protects neurons from glial activation, neuroinflammation, and oxidative stress.
• Crosses the blood-brain barrier and remains active in neural tissue for extended periods.
• Has demonstrated restorative effects in Alzheimer’s disease models, showing memory recovery and increased synaptic density.

Dihexa’s unique mechanisms of action makes it a valuable research compound for exploring cognitive resilience, neuroregeneration, and neurodegenerative disease pathways.

1. Noopept – Neuroprotection

Noopept is a dipeptide-derived nootropic with rapid absorption and neuroprotective effects.

• Modulates AMPA and NMDA glutamate receptors, supporting synaptic signaling and plasticity.
• Enhances acetylcholine transmission, contributing to improved focus, memory, and recall.
• Increases NGF (nerve growth factor) and BDNF, reinforcing neuronal survival and growth.
• Provides anti-inflammatory and antioxidant effects, reducing neuronal damage from stressors.
• Has been shown to reverse memory deficits in models of neurodegeneration and aging.

Noopept’s short half-life and rapid neuroactive conversion make it a prime candidate for investigating acute cognitive enhancement, synaptic signaling, and neuroprotection in preclinical settings.

Synergistic Effects of J-147, Dihexa, and Noopept

BioMind contains three complementary neuroactive compounds that interact to support cognitive enhancement and neuroprotection:

• J-147 increases BDNF and promotes mitochondrial function, creating a favorable environment for synaptic plasticity.
• Dihexa enhances neural connectivity and synaptic repair, making new neural pathways more resilient.
• Noopept amplifies neurotransmission efficiency, improving short-term memory and cognitive processing.

Together, these compounds provide a unique opportunity to study neurodegeneration, cognitive enhancement, and neuronal repair mechanisms in a multi-target research framework.

Molecular Structure and Data

J-147

• Chemical Name: N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N’-(3-methoxybenzyl)hydrazine
• CAS Number: 1146963-51-0
• Molecular Formula: C₁₈H₁₇F₃N₂O₂
• Molecular Weight: 350.34 g/mol

Dihexa

• Chemical Name: N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide
• CAS Number: 1401708-83-5
• Molecular Formula: C₂₇H₄₄N₄O₅
• Molecular Weight: 504.7 g/mol

Noopept

• Chemical Name: N-phenylacetyl-L-prolylglycine ethyl ester
• CAS Number: 157115-85-0
• Molecular Formula: C₁₇H₂₂N₂O₄

Molecular Weight: 318.4 g/mol

J147 and Neuroprotection

J147 is a synthetic compound designed to combat neurodegenerative diseases, particularly Alzheimer’s disease. It has demonstrated the ability to reverse cognitive impairment in aged Alzheimer’s disease mouse models by enhancing memory and synaptic plasticity [1]. Further studies indicate that J147 improves mitochondrial function and reduces markers of brain aging, suggesting its potential as a therapeutic agent for neurodegenerative conditions [2].

Dihexa and Synaptic Growth

Dihexa is an angiotensin IV analog known for its potent neurogenic and synaptogenic effects. Research has shown that Dihexa binds with high affinity to hepatocyte growth factor (HGF), promoting synaptogenesis and enhancing cognitive function in animal models of Alzheimer’s disease [3]. In APP/PS1 mouse models, Dihexa administration rescued cognitive impairment and recovered memory via the PI3K/AKT signaling pathway [4].

Noopept and Cognitive Enhancement

Noopept is a synthetic nootropic compound recognized for its cognitive-enhancing properties. Studies have demonstrated that Noopept improves memory retention and learning capacity in animal models, suggesting its potential in addressing cognitive decline associated with aging and neurodegenerative diseases [5]. Its mechanisms include modulation of glutamatergic transmission and increased expression of neurotrophic factors, which contribute to its neuroprotective and cognitive-enhancing effects [5].

Synergistic Effects of J147, Dihexa, and Noopept

BioMind’s unique formulation combines J147’s neuroprotective properties, Dihexa’s synaptogenic effects, and Noopept’s cognitive enhancement, creating a comprehensive approach to support brain health and function. This synergistic combination offers a multifaceted strategy for promoting neuronal resilience and cognitive performance, addressing synaptic loss, cognitive decline, and neuronal damage concurrently.

Referenced Citations

1. Chen, Q., et al. (2013). “The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer’s disease mice.” Alzheimer’s Research & Therapy, 5, 25.
2. Currais, A., et al. (2019). “Elevating acetyl-CoA levels reduces aspects of brain aging.” eLife, 8, e47866.
3. Benoist, C. C., et al. (2014). “The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-Met system.” Journal of Pharmacology and Experimental Therapeutics, 351(2), 390–402.
4. Sun, X., et al. (2021). “AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway.” Frontiers in Aging Neuroscience, 13, 745.

5. Ostrovskaya, R. U., et al. (2014). “Neuroprotective properties of Noopept in experimental models of cognitive impairment.” Journal of Neural Transmission, 121(8), 957–965.

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